Trusted locations are set by each user. You tell Word which are the folders where you trust macros. A very good place to mark as a trusted location is the folder you designate to hold workgroup templates.

You should not have to run it manually. Because it is named AutoNew should run automatically when the new document is created based on the template.

You can set it up to intercept the Save Command or the Ctrl-S shortcut. You would do the latter by customizing your keyboard shortcut (and storing that shortcut in your template). If you name your macro FileSave that should intercept the save command. But, see http://word.mvps.org/FAQs/MacrosVBA/...tSavePrint.htm