It's a long shot, but you might try opening a new email. Click signature from the ribbon menu at the top. The drop down has a link that launches the signature window. Maybe accessing that window from a different place will cause it to launch.

Beyond what we've already discussed, I'm kind of shooting in the dark. A registry repair might be helpful. An online update and repair from MS might be helpful.

Anyone else have an idea of how to repair Outlook for this?

Thanks again. Another clue is that when I go to: Tools/Options/Mail Format there are 3 buttons at the bottom of window (stationery, signatures, and editor options). None of them have any effect. This suggests that a number of pieces are broken!

My computer has a bit of a different startup. It books directly to a non-admin Visitor account from which I log off and log into my Admin account. The Visitor account uses Parental Controls to limit program access. Typically when I install programs that are set to install for all users I have to play a few games to convert it to the Admin only account. I'm wondering if this is somehow killing certain parts of Outlook?