Running macros with mouse wheel?

[Peterson]

I'm striking out with searching the web -- is it possible to run a macro by having the user hold down a couple keys and roll the mouse wheel? I've got two formatting-related macros that currently are run by selecting text then using keyboard shortcuts, but they would be easier if the mouse wheel could activate them: one macro activated by one wheel direction (and repeated by each click of the wheel), and another activated by the other direction. Thanks