Sub Demo()
Application.ScreenUpdating = False
Dim i As Long
i = CLng(InputBox("Starting#?"))
With ActiveDocument.Range
  With .Find
    .ClearFormatting
    .Replacement.ClearFormatting
    .Text = "Question #([0-9]@) \(ACCCC*\)"
    .Replacement.Text = ""
    .Forward = True
    .Wrap = wdFindStop
    .Format = False
    .MatchWildcards = True
    .Execute
  End With
  Do While .Find.Found
    .Text = Replace(.Text, Split(.Text, " ")(1), "#" & i)
    i = i + 1
    .Collapse wdCollapseEnd
    .Find.Execute
  Loop
End With
Application.ScreenUpdating = True
End Sub