I'd like to have a second instance of the same excel file opened in a new window. However, the second instance should be opened physically detached from the first, such that the screen shows two of the same file side-by-side. Functionally speaking, a modification made to one instance will be reflected to the other in real-time.

Could it be done?

I can't test it but I think
click File - Options - Advanced - Scroll down to " General" - Uncheck "Ignore other applications that use DDE"

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OK. I unckeck it. What then next? FYI, I am using MS Excel 2010.

So I gather it did not solve your problem?

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No, it did not. How do I open a second instance physically detached from the first? I'd like to place each on separate monitors of a dual monitor system.

Seems to work for others ( not for me I'm on Linux)
http://answers.microsoft.com/en-us/m...e3a314b?auth=1

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The link you provided clearly solves the issue of creating a second instance, but fails to address or solve the question at hand: opening the second instance in a window physically detached from the first.

Maybe the problem is with MS excel 2010, because I just happen to get access to a PC setup with 2013, and this pending issue does not seem to exist.

If this is indeed the case, I am wondering if MS provides a patch for this limitation.

I do this all the time at work.

Try...

On the View tab, in the Window group, click New Window.