One way:
Code:
Sub luxation()
Dim r As Range
Dim iRow As Long
Dim iCol As Long
Set r = ActiveSheet.UsedRange
For iCol = 1 To r.Columns.Count
For iRow = r.Rows.Count To 2 Step -1
If r(iRow, iCol).Value2 = r(iRow - 1, iCol).Value2 Then r(iRow, iCol).ClearContents
Next iRow
Next iCol
End Sub