What about if neither of the text before/after is italic? Assuming you don't want italics for the comma then either, try:
Code:
Sub Demo()
Application.ScreenUpdating = False
With ActiveDocument.Range
With .Find
.ClearFormatting
.Replacement.ClearFormatting
.Text = "[!0-9],*>"
.Replacement.Text = ""
.Forward = True
.Wrap = wdFindStop
.Format = False
.MatchWildcards = True
.Execute
End With
Do While .Find.Found
If .Words.Last.Characters(1).Font.Italic = False Then
.Characters(2).Font.Italic = False
End If
.Collapse wdCollapseEnd
.Find.Execute
Loop
End With
Application.ScreenUpdating = True
End Sub