I think you're going to have to post a workbook that actually contains some data, including examples showing what the problem data look like before and after processing. All that's in your present attachment is a bunch of formulae and nothing to relate them to.
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In order to update column C without affecting the manual data entered in columns M-P, I've made 3 columns U-V-W
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You also need to explain how changing anything in column C could affect columns M-P, since the data in those columns are manual inputs.