Hi Steve,
It is most likely that you have accidentally scroll the mouse with Clt key. Whenever, we scroll mouse with combination of clt key then screen size get increase (zoom to 50%) or decrease. Reply to any e-mail and reset the zoom to 100%. Cancel out of the e-mail (or send it if you like). The new setting will persist.
For more info, type "zoom" into the Help feature in Outlook.
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