I'd suggest you look at a number of publications of the same kind as what you're trying to produce, using approximately the same page size as you'll be publishing in (woth PDFs, of course, that's a bit noot). Consider all aspects of their page layout. Not just the margins, but also font & size, line spacing, indenting, page numbering, page headers/footers, the use of footnotes/endnotes, and so on. Look at what they do for heading fonts vs body text vs page headers/footers vs footnotes/endnotes. These could all be in different fonts. At the same time, you'll probably see minimal use of bold, underline & italics in the body text. What you probably won't find for the body text is the use of fonts that, like Calibri, lack serifs. The margins will also be somewhat larger than 1/2in.

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Cheers,
Paul Edstein
[Fmr MS MVP - Word]