The layout guides that you're using are really for equal spacing (i.e. if you want to divide the page evenly into 3 portions, etc.)

It sounds like you can use ruler guides. You can move them to anywhere on the page by just selecting and dragging, and you can have multiple ruler guides.

They can be found under Arrange -> Ruler Guides, and pick vertical or horizontal, depending on what you want for your publication. You can also just drag out these ruler guides from the rulers you see surrounding your page.

Hope that helps!