I am not saying its the problem but both Windows 7 and Excel 2010 are at end of life so i am suprised you are getting any updates at all.
Windows 7 support ended on January 14, 2020
Microsoft have released updates that have broken Windows.
Ideas
- Check that Excel is the default app for .xlsx
- Have you downloaded open office or any other office suite?
- Use excel online (doesnt work for Macros)
- Reinstall office/Wins 7/10
You might just have to open the workbook via Excel if you cant upgrade