At our office we are experiencing a problem with a handful of users when they reply to an Email Outlook with go into "Not Responding" and not come back. Doing an End Task does not kill Outlook and they have to do a restart of the computer. This is Random and after a restart it will be fine for up to a week before it happens again.

Office 2016 32 bit
Office 2019 32 bit
Windows 2004