How are you accessing your email?
Do you have a different email address you could forward the email to, and see if you still have the problem?
Quote:
I sent myself one of my own files
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Was that the same file type, eg XLSX? If yes, send yourself a different non-Office file, eg TXT.
Trying to narrow down which app is the problem…
Quote:
I just upgraded my computer to Windows 10
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That suggests a system change somewhere, probably security related, especially if you came from Win7 or earlier.
Check the Protected View in the Trust Center. Disable all the protections, & close all Office programs. Try again.
If that solved it, you probably want to re-enable the protections once you've saved the file—they're there for good reasons.