Amazing-- I have to test this and see if it works. I hadn't thought of doing a find/replace leaving the find and replace windows empty altogether and only specifying the font type and pt. But I just tried setting up such and find and replace and it seemed to accept it. I didn't execute it, but that would really change my life :-)
I'll make a test copy of my file, implement it, and see if it works.

In reply to your question, the punctuation marks in Nirmala font are not good so I have to switch them all out with Times Sanskrit punctuation. That I do via find/replace as well, but one has to be very careful with it especially with the directional quote marks, as sometimes the find/replace swaps out the wrong direction quote mark. It just takes time to do all this.