No problem.
You can use a standard range in the Worksheet_SelectionChange macro by restricting things to specific column and rows,
for example column E and rows 4 to 20.
Code:
Private Sub Worksheet_SelectionChange(ByVal Target As Range)
'limit to single cell selection
If Target.Count > 1 Then Exit Sub
'limit to specific column
If Target.Column <> 5 Then Exit Sub
'limit to specific rows
If Target.Row < 4 Or Target.Row > 20 Then Exit Sub
' do what's required, example
MsgBox "The sheet address of the cell you just entered is " & Target.Address
'
End Sub